The leaf damage is from insects. It could be any number of possibilities so unless you can find the culprit, it is not possible to say for sure.  If the insects are gone, there is no need to do anything further.  If you are able to find them, there are insecticides that are approved for edible plants.  The two branches fall down may be due to the amount of berries or may just be too long.  You can prune them back a ways if you wish.